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Science 6 September 1963:
Vol. 141. no. 3584, pp. 901 - 902
DOI: 10.1126/science.141.3584.901
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Articles

Acetylcholine-like Activity in Sciatic Nerve

E. A. Carlini 1 and J. P. Green 1

1 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut

Extracts of sciatic nerve exhibit acetylcholine-like activity that is only partly attributable to acetylcholine. The extracts show relatively greater activity on the rectus abdominis muscle of the frog than on the ileum of the guinea pig. To prevent the action of the extract on the frog rectus abdominis muscle, a greater concentration of d-tubocurarine is required than is necessary to prevent the action of known acetylcholine.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)