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Science 30 July 2004:
Vol. 305. no. 5684, pp. 671 - 673
DOI: 10.1126/science.1100330
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Reports

The Complete Genome Sequence of Propionibacterium Acnes, a Commensal of Human Skin

Holger Brüggemann,1*{dagger} Anke Henne,1 Frank Hoster,1 Heiko Liesegang,1 Arnim Wiezer,1 Axel Strittmatter,1 Sandra Hujer,2 Peter Dürre,2 Gerhard Gottschalk1{dagger}

Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes–associated diseases.

1 Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Göttingen, Grisebachstraße 8, 37077 Göttingen, Germany.
2 Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany.



* Present address: Institut Pasteur, Laboratory of Genomics of Microbial Pathogens, 28 Rue du Dr. Roux, 75724 Paris, France.

{dagger} To whom correspondence should be addressed. E-mail: hbruegg{at}pasteur.fr (H.B.) and ggottsc{at}gwdg.de (G.G.)

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