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Science 17 March 2006:
Vol. 311. no. 5767, pp. 1566 - 1570
DOI: 10.1126/science.1119426
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Review

Ambient Mass Spectrometry

R. Graham Cooks1*, Zheng Ouyang1, Zoltan Takats1,2 and Justin M. Wiseman1

1 Purdue University, Department of Chemistry, West Lafayette, IN 47907, USA.
2 Institute of Structural Chemistry, Chemical Research Centre of the Hungarian Academy of Sciences, Pusztaszeri ut 59-67, Budapest, Hungary.


Figure 1 Fig. 1. DESI (upper) and DART (lower) analyses for ambient high-throughput mass spectrometric analysis of unprepared samples (skin, bricks, urine spots, clothing, tissue, etc.). [View Larger Version of this Image (28K GIF file)]
 

Figure 2 Fig. 2. DESI mass spectrum of dried, 2-µL, raw urine spots on paper, sprayed with 1:1 methanol:water containing 1% acetic acid. The product ion MS/MS spectrum identifies one of the minor components, with m/z = 214, as aspartyl-4-phosphate. [View Larger Version of this Image (16K GIF file)]
 

Figure 3 Fig. 3. Explosives detected at low levels on various surfaces, in the positive- and negative-ion modes, showing the mass spectrum of 30-pg RDX (TNT, trinitrotoluene; RDX, hexahydrotrinitro-1,3,5-triazine; HMX, octahydro-MX H1,3,5,7-tetranitro-1,3,5,7-tetrazocine; PETN, pentaerythritol tetranitrate; TATP, triacetonetriperoxide). [View Larger Version of this Image (34K GIF file)]
 

Figure 4 Fig. 4. Areas of application of the ambient MS method of DESI, grouped into three broad overlapping classes. [View Larger Version of this Image (57K GIF file)]
 

Figure 5 Fig. 5. Direct tissue profiling of human liver adenocarcinoma using DESI in the positive-ion mode. The tissue was sectioned and untreated, and it was subjected to a spray of 1:1 methanol:water containing 0.1% ammonium hydroxide. Adapted from (32). [View Larger Version of this Image (40K GIF file)]
 

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