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Science 24 January 1997:
Vol. 275. no. 5299, pp. 453 - 0
DOI: 10.1126/science.275.5299.453i
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During development, axons extend from the neuronal cell body to the target, where the axon terminal changes to form synapses. Sone et al. (p. 543) screened Drosophila for mutations in which this process is defective. Mutations of the Still life protein showed abnormal motor activity, as well as defects, in both axon extension and synapse development. The still life gene encodes a guanine nucleotide exchange factor that is localized in the synaptic terminals, where it affects the actin cytoskeleton.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)