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Science 23 April 1999:
Vol. 284. no. 5414, pp. 665 - 667
DOI: 10.1126/science.284.5414.665
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Reports

Male Homosexuality: Absence of Linkage to Microsatellite Markers at Xq28

George Rice, 1* Carol Anderson, 1 Neil Risch, 2 George Ebers 1

Several lines of evidence have implicated genetic factors in homosexuality. The most compelling observation has been the report of genetic linkage of male homosexuality to microsatellite markers on the X chromosome. This observation warranted further study and confirmation. Sharing of alleles at position Xq28 was studied in 52 gay male sibling pairs from Canadian families. Four markers at Xq28 were analyzed (DXS1113, BGN, Factor 8, and DXS1108). Allele and haplotype sharing for these markers was not increased over expectation. These results do not support an X-linked gene underlying male homosexuality.

1 Department of Clinical Neurological Sciences, University of Western Ontario, 339 Windermere Road, London, Ontario, Canada, N6A 5A5.
2 Department of Genetics, Stanford Medical School, Palo Alto, CA 94305-5120, USA.
*   To whom correspondence should be addressed. E-mail grice{at}julian.uwo.ca

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