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Science 26 May 2000:
Vol. 288. no. 5470, pp. 1379 - 1384
DOI: 10.1126/science.288.5470.1379
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Review

Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids

Kim Nasmyth, * Jan-Michael Peters, Frank Uhlmann

In eukaryotic cells, sister DNA molecules remain physically connected from their production at S phase until their separation during anaphase. This cohesion is essential for the separation of sister chromatids to opposite poles of the cell at mitosis. It also permits chromosome segregation to take place long after duplication has been completed. Recent work has identified a multisubunit complex called cohesin that is essential for connecting sisters. Proteolytic cleavage of one of cohesin's subunits may trigger sister separation at the onset of anaphase.

Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
*   To whom correspondence should be addressed. E-mail: nasmyth{at}nt.imp.univie.ac.at

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Z. Wang, I. B. Castaño, A. De Las Peñas, C. Adams, and M. F. Christman (2000)
Science 289, 774-779
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Human Chromatid Cohesin Component hRad21 Is Phosphorylated in M Phase and Associated with Metaphase Centromeres.
Md. T. Hoque and F. Ishikawa (2001)
J. Biol. Chem. 276, 5059-5067
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Inhibition of APC-mediated proteolysis by the meiosis-specific protein kinase Ime2.
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PNAS 99, 4385-4390
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