Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 August 2000:
Vol. 289. no. 5481, pp. 950 - 953
DOI: 10.1126/science.289.5481.950
Prev | Table of Contents | Next

Reports

Inhibition of Adipogenesis by Wnt Signaling

Sarah E. Ross,1 Nahid Hemati,1 Kenneth A. Longo,1 Christina N. Bennett,1 Peter C. Lucas,2 Robin L. Erickson,1 Ormond A. MacDougald1*

Wnts are secreted signaling proteins that regulate developmental processes. Here we show that Wnt signaling, likely mediated by Wnt-10b, is a molecular switch that governs adipogenesis. Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors CCAAT/enhancer binding protein alpha  (C/EBPalpha ) and peroxisome proliferator- activated receptor gamma  (PPARgamma ). When Wnt signaling in preadipocytes is prevented by overexpression of Axin or dominant-negative TCF4, these cells differentiate into adipocytes. Disruption of Wnt signaling also causes transdifferentiation of myoblasts into adipocytes in vitro, highlighting the importance of this pathway not only in adipocyte differentiation but also in mesodermal cell fate determination.

1 Department of Physiology,
2 Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0622, USA.
*   To whom correspondence should be addressed. E-mail: macdouga{at}umich.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Fat Cell Mass by Insulin in Drosophila melanogaster.
J. R. DiAngelo and M. J. Birnbaum (2009)
Mol. Cell. Biol. 29, 6341-6352
   Abstract »    Full Text »    PDF »
Can faulty antennae increase adiposity? The link between cilia proteins and obesity.
P. Sen Gupta, N. V Prodromou, and J P. Chapple (2009)
J. Endocrinol. 203, 327-336
   Abstract »    Full Text »    PDF »
Inflammation and impaired adipogenesis in hypertrophic obesity in man.
B. Gustafson, S. Gogg, S. Hedjazifar, L. Jenndahl, A. Hammarstedt, and U. Smith (2009)
Am J Physiol Endocrinol Metab 297, E999-E1003
   Abstract »    Full Text »    PDF »
The origin of intermuscular adipose tissue and its pathophysiological implications.
R. Vettor, G. Milan, C. Franzin, M. Sanna, P. De Coppi, R. Rizzuto, and G. Federspil (2009)
Am J Physiol Endocrinol Metab 297, E987-E998
   Abstract »    Full Text »    PDF »
Genetic Variants of TCF7L2 Are Associated with Insulin Resistance and Related Metabolic Phenotypes in Taiwanese Adolescents and Caucasian Young Adults.
P.-H. Liu, Y.-C. Chang, Y.-D. Jiang, W. J. Chen, T.-J. Chang, S.-S. Kuo, K.-C. Lee, P.-C. Hsiao, K. C. Chiu, and L.-M. Chuang (2009)
J. Clin. Endocrinol. Metab. 94, 3575-3582
   Abstract »    Full Text »    PDF »
Axin expression in thymic stromal cells contributes to an age-related increase in thymic adiposity and is associated with reduced thymopoiesis independently of ghrelin signaling.
H. Yang, Y.-H. Youm, Y. Sun, J.-S. Rim, C. J. Galban, B. Vandanmagsar, and V. D. Dixit (2009)
J. Leukoc. Biol. 85, 928-938
   Abstract »    Full Text »    PDF »
Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach.
J. R.B. Perry, M. I. McCarthy, A. T. Hattersley, E. Zeggini, the Wellcome Trust Case Control Consortium, M. N. Weedon, and T. M. Frayling (2009)
Diabetes 58, 1463-1467
   Abstract »    Full Text »    PDF »
Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone.
C. Dasgupta, R. Sakurai, Y. Wang, P. Guo, N. Ambalavanan, J. S. Torday, and V. K. Rehan (2009)
Am J Physiol Lung Cell Mol Physiol 296, L1031-L1041
   Abstract »    Full Text »    PDF »
Genetic Fate Mapping Identifies Second Heart Field Progenitor Cells As a Source of Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy.
R. Lombardi, J. Dong, G. Rodriguez, A. Bell, T. K. Leung, R. J. Schwartz, J. T. Willerson, R. Brugada, and A. J. Marian (2009)
Circ. Res. 104, 1076-1084
   Abstract »    Full Text »    PDF »
Pathophysiological aspects of Wnt-signaling in endocrine disease.
S. Schinner, H. S Willenberg, M. Schott, and W. A Scherbaum (2009)
Eur. J. Endocrinol. 160, 731-737
   Abstract »    Full Text »    PDF »
COUP-TFII acts downstream of Wnt/{beta}-catenin signal to silence PPAR{gamma} gene expression and repress adipogenesis.
M. Okamura, H. Kudo, K.-i. Wakabayashi, T. Tanaka, A. Nonaka, A. Uchida, S. Tsutsumi, I. Sakakibara, M. Naito, T. F. Osborne, et al. (2009)
PNAS 106, 5819-5824
   Abstract »    Full Text »    PDF »
Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells.
G. Liu, S. Vijayakumar, L. Grumolato, R. Arroyave, H. Qiao, G. Akiri, and S. A. Aaronson (2009)
J. Cell Biol. 185, 67-75
   Abstract »    Full Text »    PDF »
Transcriptional control of brown adipocyte development and physiological function--of mice and men.
P. Seale, S. Kajimura, and B. M. Spiegelman (2009)
Genes & Dev. 23, 788-797
   Abstract »    Full Text »    PDF »
Bidirectional Modulation of Adipogenesis by the Secreted Protein Ccdc80/DRO1/URB.
F. Tremblay, T. Revett, C. Huard, Y. Zhang, J. F. Tobin, R. V. Martinez, and R. E. Gimeno (2009)
J. Biol. Chem. 284, 8136-8147
   Abstract »    Full Text »    PDF »
Regulation of Myogenic Differentiation by Androgens: Cross Talk between Androgen Receptor/ {beta}-Catenin and Follistatin/Transforming Growth Factor-{beta} Signaling Pathways.
R. Singh, S. Bhasin, M. Braga, J. N. Artaza, S. Pervin, W. E. Taylor, V. Krishnan, S. K. Sinha, T. B. Rajavashisth, and R. Jasuja (2009)
Endocrinology 150, 1259-1268
   Abstract »    Full Text »    PDF »
Dact1, a Nutritionally Regulated Preadipocyte Gene, Controls Adipogenesis by Coordinating the Wnt/{beta}-Catenin Signaling Network.
C. Lagathu, C. Christodoulides, S. Virtue, W. P. Cawthorn, C. Franzin, W. A. Kimber, E. D. Nora, M. Campbell, G. Medina-Gomez, B. N.R. Cheyette, et al. (2009)
Diabetes 58, 609-619
   Abstract »    Full Text »    PDF »
Polyunsaturated Fatty Acids Modulate the Effect of TCF7L2 Gene Variants on Postprandial Lipemia.
D. Warodomwichit, D. K. Arnett, E. K. Kabagambe, M. Y. Tsai, J. E. Hixson, R. J. Straka, M. Province, P. An, C.-Q. Lai, I. Borecki, et al. (2009)
J. Nutr. 139, 439-446
   Abstract »    Full Text »    PDF »
Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation.
V. Marion, C. Stoetzel, D. Schlicht, N. Messaddeq, M. Koch, E. Flori, J. M. Danse, J.-L. Mandel, and H. Dollfus (2009)
PNAS 106, 1820-1825
   Abstract »    Full Text »    PDF »
Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of {beta}-catenin.
K. Tilgner, K. Wojciechowicz, C. Jahoda, C. Hutchison, and E. Markiewicz (2009)
J. Cell Sci. 122, 401-413
   Abstract »    Full Text »    PDF »
The role of Dickkopf-1 in bone development, homeostasis, and disease.
J. J. Pinzone, B. M. Hall, N. K. Thudi, M. Vonau, Y.-W. Qiang, T. J. Rosol, and J. D. Shaughnessy Jr (2009)
Blood 113, 517-525
   Abstract »    Full Text »    PDF »
SPARC Inhibits Adipogenesis by Its Enhancement of {beta}-Catenin Signaling.
J. Nie and E. H. Sage (2009)
J. Biol. Chem. 284, 1279-1290
   Abstract »    Full Text »    PDF »
LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling.
J. Terrand, V. Bruban, L. Zhou, W. Gong, Z. El Asmar, P. May, K. Zurhove, P. Haffner, C. Philippe, E. Woldt, et al. (2009)
J. Biol. Chem. 284, 381-388
   Abstract »    Full Text »    PDF »
Gene expression patterns during intramuscular fat development in cattle.
Y. H. Wang, N. I. Bower, A. Reverter, S. H. Tan, N. De Jager, R. Wang, S. M. McWilliam, L. M. Cafe, P. L. Greenwood, and S. A. Lehnert (2009)
J Anim Sci 87, 119-130
   Abstract »    Full Text »    PDF »
Regulation of Cyclin D1 and Wnt10b Gene Expression by cAMP-responsive Element-binding Protein during Early Adipogenesis Involves Differential Promoter Methylation.
K. E. Fox, L. A. Colton, P. F. Erickson, J. E. Friedman, H. C. Cha, P. Keller, O. A. MacDougald, and D. J. Klemm (2008)
J. Biol. Chem. 283, 35096-35105
   Abstract »    Full Text »    PDF »
Identification of genes downregulated during differentiation of porcine mesenteric adipocytes.
S. Suzuki, S. Sembon, M. Iwamoto, D. Fuchimoto, and A. Onishi (2008)
J Anim Sci 86, 3367-3376
   Abstract »    Full Text »    PDF »
Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance.
L. Nikonova, R. A. Koza, T. Mendoza, P.-M. Chao, J. P. Curley, and L. P. Kozak (2008)
FASEB J 22, 3925-3937
   Abstract »    Full Text »    PDF »
Impact of TCF7L2 rs7903146 on Insulin Secretion and Action in Young and Elderly Danish Twins.
L. Wegner, M. S. Hussain, K. Pilgaard, T. Hansen, O. Pedersen, A. Vaag, and P. Poulsen (2008)
J. Clin. Endocrinol. Metab. 93, 4013-4019
   Abstract »    Full Text »    PDF »
Inhibitor of DNA Binding 2 Is a Small Molecule-Inducible Modulator of Peroxisome Proliferator-Activated Receptor-{gamma} Expression and Adipocyte Differentiation.
K. W. Park, H. Waki, C. J. Villanueva, L. A. Monticelli, C. Hong, S. Kang, O. A. MacDougald, A. W. Goldrath, and P. Tontonoz (2008)
Mol. Endocrinol. 22, 2038-2048
   Abstract »    Full Text »    PDF »
Msx2 Exerts Bone Anabolism via Canonical Wnt Signaling.
S.-L. Cheng, J.-S. Shao, J. Cai, O. L. Sierra, and D. A. Towler (2008)
J. Biol. Chem. 283, 20505-20522
   Abstract »    Full Text »    PDF »
Phosphorylation of CCAAT/Enhancer-binding Protein {alpha} Regulates GLUT4 Expression and Glucose Transport in Adipocytes.
H. C. Cha, N. R. Oak, S. Kang, T.-A. Tran, S. Kobayashi, S.-H. Chiang, D. G. Tenen, and O. A. MacDougald (2008)
J. Biol. Chem. 283, 18002-18011
   Abstract »    Full Text »    PDF »
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.
Y.-J. Liu, X.-G. Liu, L. Wang, C. Dina, H. Yan, J.-F. Liu, S. Levy, C. J. Papasian, B. M. Drees, J. J. Hamilton, et al. (2008)
Hum. Mol. Genet. 17, 1803-1813
   Abstract »    Full Text »    PDF »
Sca-1-Expressing Nonmyogenic Cells Contribute to Fibrosis in Aged Skeletal Muscle.
M. Hidestrand, S. Richards-Malcolm, C. M. Gurley, G. Nolen, B. Grimes, A. Waterstrat, G. V. Zant, and C. A. Peterson (2008)
J. Gerontol. A Biol. Sci. Med. Sci. 63, 566-579
   Abstract »    Full Text »    PDF »
Fat-specific Protein 27 Regulates Storage of Triacylglycerol.
P. Keller, J. T. Petrie, P. De Rose, I. Gerin, W. S. Wright, S.-H. Chiang, A. R. Nielsen, C. P. Fischer, B. K. Pedersen, and O. A. MacDougald (2008)
J. Biol. Chem. 283, 14355-14365
   Abstract »    Full Text »    PDF »
The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/{beta}-Catenin Signaling Pathways.
W. Guo, J. Flanagan, R. Jasuja, J. Kirkland, L. Jiang, and S. Bhasin (2008)
J. Biol. Chem. 283, 9136-9145
   Abstract »    Full Text »    PDF »
Modulation of Dickkopf-1 Attenuates Glucocorticoid Induction of Osteoblast Apoptosis, Adipocytic Differentiation, and Bone Mass Loss.
F.-S. Wang, J.-Y. Ko, D.-W. Yeh, H.-C. Ke, and H.-L. Wu (2008)
Endocrinology 149, 1793-1801
   Abstract »    Full Text »    PDF »
Gene Expression Analyses in Cynomolgus Monkeys Provides Mechanistic Insight into High-Density Lipoprotein-Cholesterol Reduction by Androgens in Primates.
P. Nantermet, S.-i. Harada, Y. Liu, S. Cheng, C. Johnson, Y. Yu, D. Kimme, D. Holder, P. Hodor, R. Phillips, et al. (2008)
Endocrinology 149, 1551-1561
   Abstract »    Full Text »    PDF »
Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation.
Z. Liu and J. F. Habener (2008)
J. Biol. Chem. 283, 8723-8735
   Abstract »    Full Text »    PDF »
A small-molecule inhibitor of Tcf/{beta}-catenin signaling down-regulates PPAR{gamma} and PPAR{delta} activities.
S. Handeli and J. A. Simon (2008)
Mol. Cancer Ther. 7, 521-529
   Abstract »    Full Text »    PDF »
Wnt/Notch signalling and information processing during development.
P. Hayward, T. Kalmar, and A. Martinez Arias (2008)
Development 135, 411-424
   Abstract »    Full Text »    PDF »
FAD24 Acts in Concert with Histone Acetyltransferase HBO1 to Promote Adipogenesis by Controlling DNA Replication.
Y. Johmura, S. Osada, M. Nishizuka, and M. Imagawa (2008)
J. Biol. Chem. 283, 2265-2274
   Abstract »    Full Text »    PDF »
Osteoblasts Directly Control Lineage Commitment of Mesenchymal Progenitor Cells through Wnt Signaling.
H. Zhou, W. Mak, Y. Zheng, C. R. Dunstan, and M. J. Seibel (2008)
J. Biol. Chem. 283, 1936-1945
   Abstract »    Full Text »    PDF »
Pitx2 Prevents Osteoblastic Transdifferentiation of Myoblasts by Bone Morphogenetic Proteins.
M. Hayashi, S. Maeda, H. Aburatani, K. Kitamura, H. Miyoshi, K. Miyazono, and T. Imamura (2008)
J. Biol. Chem. 283, 565-571
   Abstract »    Full Text »    PDF »
Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis.
J. H. Cheng, H. She, Y.-P. Han, J. Wang, S. Xiong, K. Asahina, and H. Tsukamoto (2008)
Am J Physiol Gastrointest Liver Physiol 294, G39-G49
   Abstract »    Full Text »    PDF »
Inflamed Adipose Tissue: A Culprit Underlying the Metabolic Syndrome and Atherosclerosis.
B. Gustafson, A. Hammarstedt, C. X. Andersson, and U. Smith (2007)
Arterioscler Thromb Vasc Biol 27, 2276-2283
   Abstract »    Full Text »    PDF »
WNT10B Functional Dualism: beta-Catenin/Tcf-dependent Growth Promotion or Independent Suppression with Deregulated Expression in Cancer.
H. Yoshikawa, K. Matsubara, X. Zhou, S. Okamura, T. Kubo, Y. Murase, Y. Shikauchi, M. Esteller, J. G. Herman, X. Wei Wang, et al. (2007)
Mol. Biol. Cell 18, 4292-4303
   Abstract »    Full Text »    PDF »
Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes.
J. Y. Kim, Y. Wu, and C. M. Smas (2007)
Physiol Genomics 31, 328-342
   Abstract »    Full Text »    PDF »
Oxidative Stress Antagonizes Wnt Signaling in Osteoblast Precursors by Diverting beta-Catenin from T Cell Factor- to Forkhead Box O-mediated Transcription.
M. Almeida, L. Han, M. Martin-Millan, C. A. O'Brien, and S. C. Manolagas (2007)
J. Biol. Chem. 282, 27298-27305
   Abstract »    Full Text »    PDF »
Wnt/{beta}-Catenin Signaling Stimulates Chondrogenic and Inhibits Adipogenic Differentiation of Pericytes: Potential Relevance to Vascular Disease?.
J. P. Kirton, N. J. Crofts, S. J. George, K. Brennan, and A. E. Canfield (2007)
Circ. Res. 101, 581-589
   Abstract »    Full Text »    PDF »
Variation of the Transcription Factor 7-Like 2 (TCF7L2) Gene Predicts Impaired Fasting Glucose in Healthy Young Adults: The Cardiovascular Risk in Young Finns Study.
O. T. Raitakari, T. Ronnemaa, R. Huupponen, L. Viikari, M. Fan, J. Marniemi, N. Hutri-Kahonen, J. S.A. Viikari, and T. Lehtimakimd (2007)
Diabetes Care 30, 2299-2301
   Full Text »    PDF »
Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats.
G. Aslanidi, V. Kroutov, G. Philipsberg, K. Lamb, M. Campbell-Thompson, G. A. Walter, S. Kurenov, J. Ignacio Aguirre, P. Keller, K. Hankenson, et al. (2007)
Am J Physiol Endocrinol Metab 293, E726-E736
   Abstract »    Full Text »    PDF »
TRB2, a Mouse Tribbles Ortholog, Suppresses Adipocyte Differentiation by Inhibiting AKT and C/EBPbeta.
T. Naiki, E. Saijou, Y. Miyaoka, K. Sekine, and A. Miyajima (2007)
J. Biol. Chem. 282, 24075-24082
   Abstract »    Full Text »    PDF »
Chibby Promotes Adipocyte Differentiation through Inhibition of {beta}-Catenin Signaling.
F.-Q. Li, A. M. Singh, A. Mofunanya, D. Love, N. Terada, R. T. Moon, and K.-I. Takemaru (2007)
Mol. Cell. Biol. 27, 4347-4354
   Abstract »    Full Text »    PDF »
Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-{alpha}, CH11 and CYC202.
M. Mody, N. Dharker, M. Bloomston, P.-S. Wang, F.-S. Chou, T. S Glickman, T. McCaffrey, Z. Yang, A. Pumfery, D. Lee, et al. (2007)
Endocr. Relat. Cancer 14, 305-315
   Abstract »    Full Text »    PDF »
Thematic review series: Adipocyte Biology. Adipose tissue function and plasticity orchestrate nutritional adaptation.
J. K. Sethi and A. J. Vidal-Puig (2007)
J. Lipid Res. 48, 1253-1262
   Abstract »    Full Text »    PDF »
Effects of Thiazolidinediones on Differentiation, Proliferation, and Apoptosis.
F.-S. Chou, P.-S. Wang, S. Kulp, and J. J. Pinzone (2007)
Mol. Cancer Res. 5, 523-530
   Abstract »    Full Text »    PDF »
In Vivo Analysis of Wnt Signaling in Bone.
D. A. Glass II and G. Karsenty (2007)
Endocrinology 148, 2630-2634
   Abstract »    Full Text »    PDF »
Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein {alpha} and Peroxisome Proliferator-activated Receptor {gamma}.
S. Kang, C. N. Bennett, I. Gerin, L. A. Rapp, K. D. Hankenson, and O. A. MacDougald (2007)
J. Biol. Chem. 282, 14515-14524
   Abstract »    Full Text »    PDF »
TCF7L2 Gene Polymorphisms Confer an Increased Risk for Early Impairment of Glucose Metabolism and Increased Height in Obese Children.
A. Korner, J. Berndt, M. Stumvoll, W. Kiess, and P. Kovacs (2007)
J. Clin. Endocrinol. Metab. 92, 1956-1960
   Abstract »    Full Text »    PDF »
Wnt signaling interacts with Shh to regulate taste papilla development.
K. Iwatsuki, H.-X. Liu, A. Gronder, M. A. Singer, T. F. Lane, R. Grosschedl, C. M. Mistretta, and R. F. Margolskee (2007)
PNAS 104, 2253-2258
   Abstract »    Full Text »    PDF »
Wnt10b Inhibits Obesity in ob/ob and Agouti Mice.
W. S. Wright, K. A. Longo, V. W. Dolinsky, I. Gerin, S. Kang, C. N. Bennett, S.-H. Chiang, T. C. Prestwich, C. Gress, C. F. Burant, et al. (2007)
Diabetes 56, 295-303
   Abstract »    Full Text »    PDF »
Differential Gene Expression Profile in Omental Adipose Tissue in Women with Polycystic Ovary Syndrome.
M. Corton, J. I. Botella-Carretero, A. Benguria, G. Villuendas, A. Zaballos, J. L. San Millan, H. F. Escobar-Morreale, and B. Peral (2007)
J. Clin. Endocrinol. Metab. 92, 328-337
   Abstract »    Full Text »    PDF »
Depletion of cAMP-response Element-binding Protein/ATF1 Inhibits Adipogenic Conversion of 3T3-L1 Cells Ectopically Expressing CCAAT/Enhancer-binding Protein (C/EBP) {alpha}, C/EBP beta, or PPAR{gamma}2.
K. E. Fox, D. M. Fankell, P. F. Erickson, S. M. Majka, J. T. Crossno Jr., and D. J. Klemm (2006)
J. Biol. Chem. 281, 40341-40353
   Abstract »    Full Text »    PDF »
Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue.
T. P. Ciaraldi, D. K. Oh, L. Christiansen, S. E. Nikoulina, A. P. S. Kong, S. Baxi, S. Mudaliar, and R. R. Henry (2006)
Am J Physiol Endocrinol Metab 291, E891-E898
   Abstract »    Full Text »    PDF »
Wnt/beta-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone.
J. A. Robinson, M. Chatterjee-Kishore, P. J. Yaworsky, D. M. Cullen, W. Zhao, C. Li, Y. Kharode, L. Sauter, P. Babij, E. L. Brown, et al. (2006)
J. Biol. Chem. 281, 31720-31728
   Abstract »    Full Text »    PDF »
Peroxisome Proliferator-Activated Receptor {alpha} Activation during Pregnancy Severely Impairs Mammary Lobuloalveolar Development in Mice.
Q. Yang, R. Kurotani, A. Yamada, S. Kimura, and F. J. Gonzalez (2006)
Endocrinology 147, 4772-4780
   Abstract »    Full Text »    PDF »
Ectopic expression of C/EBP{alpha} in the lung epithelium disrupts late lung development.
T. Berg, L. Didon, and M. Nord (2006)
Am J Physiol Lung Cell Mol Physiol 291, L683-L693
   Abstract »    Full Text »    PDF »
Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study.
Y.-f. Guo, D.-h. Xiong, H. Shen, L.-j. Zhao, P. Xiao, Y. Guo, W. Wang, T.-l. Yang, R. R Recker, and H.-w. Deng (2006)
J. Med. Genet. 43, 798-803
   Abstract »    Full Text »    PDF »
Polymorphisms in the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in the Amish: Replication and Evidence for a Role in Both Insulin Secretion and Insulin Resistance.
C. M. Damcott, T. I. Pollin, L. J. Reinhart, S. H. Ott, H. Shen, K. D. Silver, B. D. Mitchell, and A. R. Shuldiner (2006)
Diabetes 55, 2654-2659
   Abstract »    Full Text »    PDF »
Dual Regulation of Rho and Rac by p120 Catenin Controls Adipocyte Plasma Membrane Trafficking.
J. C. Hou, S. Shigematsu, H. C. Crawford, P. Z. Anastasiadis, and J. E. Pessin (2006)
J. Biol. Chem. 281, 23307-23312
   Abstract »    Full Text »    PDF »
Functional Interaction between Peroxisome Proliferator-Activated Receptor {gamma} and {beta}-Catenin.
J. Liu, H. Wang, Y. Zuo, and S. R. Farmer (2006)
Mol. Cell. Biol. 26, 5827-5837
   Abstract »    Full Text »    PDF »
Role of Adipose Tissue as an Inflammatory Organ in Human Diseases.
A. Schaffler, U. Muller-Ladner, J. Scholmerich, and C. Buchler (2006)
Endocr. Rev. 27, 449-467
   Abstract »    Full Text »    PDF »
Muscle stem cells in development, regeneration, and disease..
X. Shi and D. J. Garry (2006)
Genes & Dev. 20, 1692-1708
   Abstract »    Full Text »    PDF »
Upregulation of gene encoding adipogenic transcriptional factors C/EBP{alpha} and PPAR{gamma}2 in denervated muscle.
A. Wagatsuma (2006)
Exp Physiol 91, 747-753
   Abstract »    Full Text »    PDF »
The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis.
C. Christodoulides, M. Laudes, W. P. Cawthorn, S. Schinner, M. Soos, S. O'Rahilly, J. K. Sethi, and A. Vidal-Puig (2006)
J. Cell Sci. 119, 2613-2620
   Abstract »    Full Text »    PDF »
Cytokines Promote Wnt Signaling and Inflammation and Impair the Normal Differentiation and Lipid Accumulation in 3T3-L1 Preadipocytes.
B. Gustafson and U. Smith (2006)
J. Biol. Chem. 281, 9507-9516
   Abstract »    Full Text »    PDF »
Activation of CCAAT/Enhancer-binding Protein (C/EBP) {alpha} Expression by C/EBPbeta during Adipogenesis Requires a Peroxisome Proliferator-activated Receptor-{gamma}-associated Repression of HDAC1 at the C/ebp{alpha} Gene Promoter.
Y. Zuo, L. Qiang, and S. R. Farmer (2006)
J. Biol. Chem. 281, 7960-7967
   Abstract »    Full Text »    PDF »
Functional Analysis of Hes-1 in Preadipocytes.
D. A. Ross, S. Hannenhalli, J. W. Tobias, N. Cooch, R. Shiekhattar, and T. Kadesch (2006)
Mol. Endocrinol. 20, 698-705
   Abstract »    Full Text »    PDF »
An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPAR{gamma}, adipogenesis, and insulin-responsive hexose transport.
X. Tang, A. Guilherme, A. Chakladar, A. M. Powelka, S. Konda, J. V. Virbasius, S. M. C. Nicoloro, J. Straubhaar, and M. P. Czech (2006)
PNAS 103, 2087-2092
   Abstract »    Full Text »    PDF »
Respiratory Failure Due to Differentiation Arrest and Expansion of Alveolar Cells following Lung-Specific Loss of the Transcription Factor C/EBP{alpha} in Mice.
D. S. Basseres, E. Levantini, H. Ji, S. Monti, S. Elf, T. Dayaram, M. Fenyus, O. Kocher, T. Golub, K.-k. Wong, et al. (2006)
Mol. Cell. Biol. 26, 1109-1123
   Abstract »    Full Text »    PDF »
Testosterone Inhibits Adipogenic Differentiation in 3T3-L1 Cells: Nuclear Translocation of Androgen Receptor Complex with {beta}-Catenin and T-Cell Factor 4 May Bypass Canonical Wnt Signaling to Down-Regulate Adipogenic Transcription Factors.
R. Singh, J. N. Artaza, W. E. Taylor, M. Braga, X. Yuan, N. F. Gonzalez-Cadavid, and S. Bhasin (2006)
Endocrinology 147, 141-154
   Abstract »    Full Text »    PDF »
Interaction of Nuclear Receptors with the Wnt/{beta}-Catenin/Tcf Signaling Axis: Wnt You Like to Know?.
D. J. Mulholland, S. Dedhar, G. A. Coetzee, and C. C. Nelson (2005)
Endocr. Rev. 26, 898-915
   Abstract »    Full Text »    PDF »
Gene-nutrient interactions during fetal development.
C. A Maloney and W. D Rees (2005)
Reproduction 130, 401-410
   Abstract »    Full Text »    PDF »
The Molecular Scaffold Kinase Suppressor of Ras 1 (KSR1) Regulates Adipogenesis.
R. L. Kortum, D. L. Costanzo, J. Haferbier, S. J. Schreiner, G. L. Razidlo, M.-H. Wu, D. J. Volle, T. Mori, H. Sakaue, N. V. Chaika, et al. (2005)
Mol. Cell. Biol. 25, 7592-7604
   Abstract »    Full Text »    PDF »
Gene Expression Profiling of Orbital Adipose Tissue from Patients with Graves' Ophthalmopathy: A Potential Role for Secreted Frizzled-Related Protein-1 in Orbital Adipogenesis.
S. Kumar, A. Leontovich, M. J. Coenen, and R. S. Bahn (2005)
J. Clin. Endocrinol. Metab. 90, 4730-4735
   Abstract »    Full Text »    PDF »
Activation of the Canonical Wnt Pathway during Genital Keratinocyte Transformation: A Model for Cervical Cancer Progression.
A. Uren, S. Fallen, H. Yuan, A. Usubutun, T. Kucukali, R. Schlegel, and J. A. Toretsky (2005)
Cancer Res. 65, 6199-6206
   Abstract »    Full Text »    PDF »
Wnt Signaling Inhibits Adipogenesis through {beta}-Catenin-dependent and -independent Mechanisms.
J. A. Kennell and O. A. MacDougald (2005)
J. Biol. Chem. 280, 24004-24010
   Abstract »    Full Text »    PDF »
Wnt10b Deficiency Promotes Coexpression of Myogenic and Adipogenic Programs in Myoblasts.
A. M. Vertino, J. M. Taylor-Jones, K. A. Longo, E. D. Bearden, T. F. Lane, R. E. McGehee Jr., O. A. MacDougald, and C. A. Peterson (2005)
Mol. Biol. Cell 16, 2039-2048
   Abstract »    Full Text »    PDF »
Rosiglitazone Causes Bone Loss in Mice by Suppressing Osteoblast Differentiation and Bone Formation.
A. A. Ali, R. S. Weinstein, S. A. Stewart, A. M. Parfitt, S. C. Manolagas, and R. L. Jilka (2005)
Endocrinology 146, 1226-1235
   Abstract »    Full Text »    PDF »
Regulation of osteoblastogenesis and bone mass by Wnt10b.
C. N. Bennett, K. A. Longo, W. S. Wright, L. J. Suva, T. F. Lane, K. D. Hankenson, and O. A. MacDougald (2005)
PNAS 102, 3324-3329
   Abstract »    Full Text »    PDF »
Effects of Wnt Signaling on Brown Adipocyte Differentiation and Metabolism Mediated by PGC-1{alpha}.
S. Kang, L. Bajnok, K. A. Longo, R. K. Petersen, J. B. Hansen, K. Kristiansen, and O. A. MacDougald (2005)
Mol. Cell. Biol. 25, 1272-1282
   Abstract »    Full Text »    PDF »
Both ERK and Wnt/{beta}-catenin pathways are involved in Wnt3a-induced proliferation.
M.-S. Yun, S.-E. Kim, S. H. Jeon, J.-S. Lee, and K.-Y. Choi (2005)
J. Cell Sci. 118, 313-322
   Abstract »    Full Text »    PDF »
Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation.
K. Tominaga, Y. Johmura, M. Nishizuka, and M. Imagawa (2004)
J. Cell Sci. 117, 6217-6226
   Abstract »    Full Text »    PDF »
Genetic Determinants of Energy Expenditure and Insulin Resistance in Diet-Induced Obesity in Mice.
K. Almind and C. R. Kahn (2004)
Diabetes 53, 3274-3285
   Abstract »    Full Text »    PDF »
Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland.
M. Morroni, A. Giordano, M. C. Zingaretti, R. Boiani, R. De Matteis, B. B. Kahn, E. Nisoli, C. Tonello, C. Pisoschi, M. M. Luchetti, et al. (2004)
PNAS 101, 16801-16806
   Abstract »    Full Text »    PDF »
Regulating the Balance between Peroxisome Proliferator-activated Receptor {gamma} and {beta}-Catenin Signaling during Adipogenesis: A GLYCOGEN SYNTHASE KINASE 3{beta} PHOSPHORYLATION-DEFECTIVE MUTANT OF {beta}-CATENIN INHIBITS EXPRESSION OF A SUBSET OF ADIPOGENIC GENES.
J. Liu and S. R. Farmer (2004)
J. Biol. Chem. 279, 45020-45027
   Abstract »    Full Text »    PDF »
The Forkhead Transcription Factor FoxC2 Inhibits White Adipocyte Differentiation.
K. E. Davis, M. Moldes, and S. R. Farmer (2004)
J. Biol. Chem. 279, 42453-42461
   Abstract »    Full Text »    PDF »
EPAS1 Promotes Adipose Differentiation in 3T3-L1 Cells.
S. Shimba, T. Wada, S. Hara, and M. Tezuka (2004)
J. Biol. Chem. 279, 40946-40953
   Abstract »    Full Text »    PDF »
Role of MAPK Phosphatase-1 (MKP-1) in Adipocyte Differentiation.
H. Sakaue, W. Ogawa, T. Nakamura, T. Mori, K. Nakamura, and M. Kasuga (2004)
J. Biol. Chem. 279, 39951-39957
   Abstract »    Full Text »    PDF »
Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice.
J. Hulit, C. Wang, Z. Li, C. Albanese, M. Rao, D. Di Vizio, S. Shah, S. W. Byers, R. Mahmood, L. H. Augenlicht, et al. (2004)
Mol. Cell. Biol. 24, 7598-7611
   Abstract »    Full Text »    PDF »
Wnt10b Inhibits Development of White and Brown Adipose Tissues.
K. A. Longo, W. S. Wright, S. Kang, I. Gerin, S.-H. Chiang, P. C. Lucas, M. R. Opp, and O. A. MacDougald (2004)
J. Biol. Chem. 279, 35503-35509
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)