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Science 17 January 2003:
Vol. 299. no. 5605, pp. 355 - 356
DOI: 10.1126/science.1081277
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Perspectives

DEVELOPMENT:
What Makes an Embryo Stick?

Asgerally T. Fazleabas and J. Julie Kim

Implantation of the human embryo into the uterine lining is a crucial step during early pregnancy, yet little is known about the molecular mechanisms involved. In their Perspective, Fazleabas and Kim discuss new work (Genbacev et al.) identifying L-selectin expressed by trophoblast cells of the blastocyst as a crucial mediator of the initial interaction between the embryo and uterine lining, the first step in implantation.

The authors are in the Department of Obstetrics and Gynecology, University of Illinois, Chicago, IL 60612, USA. E-mail: asgi{at}uic.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment.
M. S. M. van Mourik, N. S. Macklon, and C. J. Heijnen (2009)
J. Leukoc. Biol. 85, 4-19
   Abstract »    Full Text »    PDF »
Endometrial receptivity markers, the journey to successful embryo implantation.
H. Achache and A. Revel (2006)
Hum. Reprod. Update 12, 731-746
   Abstract »    Full Text »    PDF »


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