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Science 8 October 2004:
Vol. 306. no. 5694, pp. 239 - 240
DOI: 10.1126/science.1104769
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Perspectives

DEVELOPMENT:
ES Cells to the Rescue

Kenneth R. Chien, Alessandra Moretti and Karl-Ludwig Laugwitz

Unlocking the therapeutic potential of embryonic stem (ES) cells has remained a tantalizing but elusive goal. In their Perspective, Chien, Moretti and Laugwitz discuss new work (Fraidenraich et al.) showing that ES cells can rescue otherwise lethal cardiac defects in mouse embryos even when injected into the peritoneum of the mother prior to conception. The rescue effect is not due to differentiation of the ES cells into cardiac cells per se, but rather to their secretion of factors that act locally or at a distance via the maternal circulation to trigger proliferation of cardiac muscle cells in the mutant mouse embryos.

The authors are in the Institute of Molecular Medicine, University of California San Diego, La Jolla, CA 92037, USA. E-mail: kchien{at}ucsd.edu

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