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Science 8 October 2004:
Vol. 306. no. 5694, pp. 286 - 289
DOI: 10.1126/science.1103066
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Reports

Genome Sequence of a Polydnavirus: Insights into Symbiotic Virus Evolution

Eric Espagne,1*{dagger} Catherine Dupuy,1{dagger}{ddagger} Elisabeth Huguet,1 Laurence Cattolico,2 Bertille Provost,1 Nathalie Martins,2 Marylène Poirié,1 Georges Periquet,1 Jean Michel Drezen1

Little is known of the fate of viruses involved in long-term obligatory associations with eukaryotes. For example, many species of parasitoid wasps have symbiotic viruses to manipulate host defenses and to allow development of parasitoid larvae. The complete nucleotide sequence of the DNA enclosed in the virus particles injected by a parasitoid wasp revealed a complex organization, resembling a eukaryote genomic region more than a viral genome. Although endocellular symbiont genomes have undergone a dramatic loss of genes, the evolution of symbiotic viruses appears to be characterized by extensive duplication of virulence genes coding for truncated versions of cellular proteins.

1 Institut de Recherche sur la Biologie de l'Insecte, CNRS UMR 6035, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France.
2 Genoscope, Centre National de Séquençage, 2 rue Gaston Crémieux, CP 5706, 91057 Evry, France.



* Present address: Institut de Génétique et Microbiologie, Université Paris Sud, Bat. 400, 91405 Orsay cedex, France.

{dagger} These authors contributed equally to this work.

{ddagger} To whom correspondence should be addressed. E-mail: catherine.dupuy{at}univ-tours.fr

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