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Target Cell-Dependent Normalization of Transmitter Release at Neocortical Synapses
Helmut J. Koester1,2* and
Daniel Johnston2*
The efficacy and short-term modification of neocortical synapticconnections vary with the type of target neuron. We investigatedpresynaptic Ca2+ and release probability at single synapticcontacts between pairs of neurons in layer 2/3 of the rat neocortex.The amplitude of Ca2+ signals in boutons of pyramids contactingbitufted or multipolar interneurons or other pyramids was dependenton the target cell type. Optical quantal analysis at singlesynaptic contacts suggested that release probabilities are alsotarget cell-specific. Both the Ca2+ signal and the release probabilityof different boutons of a pyramid contacting the same targetcell varied little. We propose that the mechanisms that regulatethe functional properties of boutons of a pyramid normalizethe presynaptic Ca2+ influx and release probability for allthose boutons that innervate the same target cell.
1 Abteilung Zellphysiologie, Max-Planck-Institut für Medizinische Forschung, Jahnstraße 29, D-69120 Heidelberg, Germany. 2 Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Published online 17 March 2005;
Include this information when citing this paper.
* Present address: Center for Learning and Memory, Universityof Texas at Austin, Austin, TX 78712, USA.
To whom correspondence should be addressed. E-mail: HKoester{at}mail.utexas.edu
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