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Science 17 March 2006:
Vol. 311. no. 5767, pp. 1563 - 1564
DOI: 10.1126/science.1125248
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Perspectives

CHEMISTRY:
Seamless Proteins Tie Up Their Loose Ends

David J. Craik

Natural circular proteins found in bacteria, plants, and mammals show antimicrobial activity and exceptional stability, making them ideal templates for engineering better drugs. But just how they close into loops remains a mystery.

The author is at the Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia. E-mail: d.craik{at}imb.uq.edu.au

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