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Science 31 March 2006:
Vol. 311. no. 5769, p. 1832
DOI: 10.1126/science.311.5769.1832p
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This Week in Science

It is no longer enough to have one sequenced genome of an organism; characterizing function and understanding diversity or evolution can require inefficient and expensive resequencing efforts. Gresham et al. (p. 1932, published online 9 March) have compared an entire yeast genome to a reference sequence represented on a microarray to rapidly locate all sequence differences. Genomes could differ by as little as one mutation or as many as 30,000. The approach was used for identifying genes related to specific traits and to track all the single-nucleotide polymorphisms that accumulate during experimental evolution of a yeast population.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)