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Science 14 April 2006:
Vol. 312. no. 5771, p. 155
DOI: 10.1126/science.312.5771.155p
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Sequences, and even expression patterns, are conserved across evolutionary history, but less is understood about the conservation of regulatory sequences. Fisher et al. (p. 276, published online 23 March) developed a rapid, transposon-based transgenic strategy in zebrafish to study the functional conservation of noncoding sequences. This assay avoided problems of mosaicism that have been observed previously. The sequences that control expression of RET in humans (a gene that is associated with neural crest disorders) also show appropriate tissue-specific expression in the zebrafish, despite the lack of overt sequence conservation between the regulatory elements.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)