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Science 26 June 2009:
Vol. 324. no. 5935, pp. 1693 - 1697
DOI: 10.1126/science.1175102
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Reports

High-Resolution NMR in Magnetic Fields with Unknown Spatiotemporal Variations

Philippe Pelupessy,1,* Enrico Rennella,2 Geoffrey Bodenhausen1,3

Nuclear magnetic resonance (NMR) experiments are usually carried out in homogeneous magnetic fields. In many cases, however, high-resolution spectra are virtually impossible to obtain because of the inherent heterogeneity of the samples or living organisms under investigation, as well as the poor homogeneity of the magnets (particularly when bulky samples must be placed outside their bores). Unstable power supplies and vibrations arising from cooling can lead to field fluctuations in time as well as space. We show how high-resolution NMR spectra can be obtained in inhomogeneous fields with unknown spatiotemporal variations. Our method, based on coherence transfer between spins, can accommodate spatial inhomogeneities of at least 11 gauss per centimeter and temporal fluctuations slower than 2 hertz.

1 Département de Chimie Associé au CNRS, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris Cedex 05, France.
2 Department of Biomedical Sciences and Technologies, Università degli Studi di Udine, I-33100 Udine, Italy.
3 Institut de Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Batochime, 1015 Lausanne, Switzerland.

* To whom correspondence should be addressed. E-mail: philippe.pelupessy{at}ens.fr

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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P. R. Vasos, A. Comment, R. Sarkar, P. Ahuja, S. Jannin, J.-P. Ansermet, J. A. Konter, P. Hautle, B. van den Brandt, and G. Bodenhausen (2009)
PNAS 106, 18469-18473
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Science. ISSN 0036-8075 (print), 1095-9203 (online)