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Science 24 January 1997:
Vol. 275. no. 5299, pp. 482 - 484
DOI: 10.1126/science.275.5299.482
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Research News

Marcia Barinaga

Traditional cancer treatments seek to attack cancer cells directly, with surgery, radiation, or chemotherapy. But a new wave of therapies is attempting an indirect strike: shutting off the blood vessels through which tumors get the oxygen and nutrients they need to live and grow. Recent work suggests that this might be done with drugs, some naturally occurring, that can prevent tumors from forming the new blood vessels they need. Alternately, as a report appearing on page 547 suggests, it might be possible to shrink or even eliminate tumors by administering agents that trigger clot formation in tumor-feeding vessels.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A hybrid fibronectin motif protein as an integrin targeting selective tumor vascular thrombogen.
C. Liu, C. Dickinson, J. Shobe, F. Donate, W. Ruf, and T. Edgington (2004)
Mol. Cancer Ther. 3, 793-801
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Angiogenesis in the Placenta.
L. P. Reynolds and D. A. Redmer (2001)
Biol Reprod 64, 1033-1040
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Remarkable Tolerance of Tumor Cells to Nutrient Deprivation: Possible New Biochemical Target for Cancer Therapy.
K. Izuishi, K. Kato, T. Ogura, T. Kinoshita, and H. Esumi (2000)
Cancer Res. 60, 6201-6207
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A Novel Animal Model for Hemangiomas: Inhibition of Hemangioma Development by the Angiogenesis Inhibitor TNP-470.
S. Liekens, E. Verbeken, M. Vandeputte, E. De Clercq, and J. Neyts (1999)
Cancer Res. 59, 2376-2383
   Abstract »    Full Text »    PDF »
Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal.
L. E. Benjamin and E. Keshet (1997)
PNAS 94, 8761-8766
   Abstract »    Full Text »    PDF »


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