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Science 26 May 2000:
Vol. 288. no. 5470, pp. 1372 - 1373
DOI: 10.1126/science.288.5470.1372
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Matching the Transcription Machinery to the Right DNA

Elizabeth Pennisi

Researchers have long known that a protein called TAFII250 is an essential part of the machinery that transcribes genes into messenger RNAs, the first step of protein synthesis. Work described on page 1422 now helps reveal just what TAFII250 does. Studies of a portion of the protein that contains two motifs called bromodomains shows that the bromodomains recognize and bind to acetyl groups attached to one of the histone proteins that wrap the DNA, forming beadlike structures called nucleosomes. This suggests that TAFII250 helps direct the transcription machinery to the right DNA targets and gets the DNA into the correct configuration for transcription to occur.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The SIN3/RPD3 Deacetylase Complex Is Essential for G2 Phase Cell Cycle Progression and Regulation of SMRTER Corepressor Levels.
L. A. Pile, E. M. Schlag, and D. A. Wassarman (2002)
Mol. Cell. Biol. 22, 4965-4976
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Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID.
T. Chimura, T. Kuzuhara, and M. Horikoshi (2002)
PNAS 99, 9334-9339
   Abstract »    Full Text »    PDF »
Hepatitis B Virus HBx Protein Activation of Cyclin A-Cyclin-Dependent Kinase 2 Complexes and G1 Transit via a Src Kinase Pathway.
M. Bouchard, S. Giannakopoulos, E. H. Wang, N. Tanese, and R. J. Schneider (2001)
J. Virol. 75, 4247-4257
   Abstract »    Full Text »


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