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Science 22 December 2000:
Vol. 290. no. 5500, p. 2222
DOI: 10.1126/science.290.5500.2222
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BREAKTHROUGH OF THE YEAR:
Peering Into 2001

Science's editors gazed into their crystal ball to predict six research areas to watch in the coming year: infectious diseases, oceans, RNA interference, research funding, quarks, and how cells tell one side from the other.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)