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Science 22 December 2000:
Vol. 290. no. 5500, p. 2225
DOI: 10.1126/science.290.5500.2225
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CONTROVERSY OF THE YEAR:
Biomedical Ethics on the Front Burner

It was a hot year for debates over research ethics. Controversy erupted in late 1999 after the death of 18-year-old Jesse Gelsinger in a gene-therapy clinical trial at the University of Pennsylvania. Because Penn and one of its clinicians had a financial stake in a gene-therapy company, questions about potential conflicts of interest arose at once.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)