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Science 18 October 2002:
Vol. 298. no. 5593, pp. 552 - 553
DOI: 10.1126/science.1077335
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Perspectives

ENZYMOLOGY:
A Trio of Transition Metals in Anaerobic CO2 Fixation

John W. Peters

Certain anaerobic microorganisms can gain energy and biomass using carbon monoxide or dioxide and dihydrogen as sole sources of carbon and energy. In his Perspective, Peters explains how new results by Doukov et al. illuminate the carbon dioxide fixation pathway. Doukov et al. report that the enzyme responsible for the process contains a highly unusual metal cluster, with three different transition metals including copper, in one of its active sites.

The author is in the Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA. E-mail: john.peters{at}chemistry.montana.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)