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Science 18 June 2004:
Vol. 304. no. 5678, pp. 1750 - 1752
DOI: 10.1126/science.1100475
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Perspectives

NEUROSCIENCE:
Vesicular Glutamate Transporter--Shooting Blanks

Kim Schuske and Erik M. Jorgensen*

Brain activity depends on the release of the neurotransmitter glutamate by exocytosis of synaptic vesicles. In their Perspective, Schuske and Jorgensen comment on two studies (Fremeau et al., Wocjik et al.) that find that mice with the main vesicular glutamate transporter knocked out survive for several months. However, the two studies present different models for subcellular localization of the vesicular transporter and for vesicle loading.

The authors are in the Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112-0840, USA. E-mail: jorgensen{at}biology.utah.edu

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