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Science 20 August 2004:
Vol. 305. no. 5687, pp. 1113 - 1114
DOI: 10.1126/science.1102692
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Perspectives

IMMUNOLOGY:
UNGstoppable Switching

Shyam Unniraman, Sebastian D. Fugmann, David G. Schatz

The enzymes AID, a DNA deaminase, and UNG are crucial for two processes (CSR and SHM) involved in the generation of antibody diversity in B cells. As Unniraman and colleagues point out in their Perspective, new findings about the action of UNG suggest a rethink of a popular model of CSR in which the central event is DNA deamination by AID (Begum et al.)

The authors are at the Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. E-mail: shyam.unniraman{at}yale.edu, sebastian.fugmann{at}yale.edu, david.schatz{at}yale.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comment on "Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch".
J. T. Stivers (2004)
Science 306, 2042b
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