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Science 5 November 2004:
Vol. 306. no. 5698, p. 937
DOI: 10.1126/science.306.5698.937i
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This Week in Science

Autophagy, the process by which cells sequester and degrade organelles and cytoplasm in times of stress, is being recognized as playing a role in a variety of disease processes. Shintani and Klionsky (p. 990; see the cover) review the sometimes paradoxical roles of autophagy in human health, disease, and aging. Nakagawa et al. (p. 1037) describe how cells can clear an invading pathogen, group A Streptococcus, by targeting the cytosolic bacteria for destruction by the cellular autophagy machinery.




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