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Science 31 March 2006:
Vol. 311. no. 5769, p. 1832
DOI: 10.1126/science.311.5769.1832o
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The immune system is classically described in terms of innate and acquired immunity, although it is becoming increasingly apparent that these two arms share some fundamental cellular and molecular processes. In large part, this overlap exists "downstream" at points of gene expression and transcriptional regulation; for example, the transcription factor NFkappaB activates a large number of innate and acquired immune response genes. Although "upstream" (membrane proximal) signaling proteins appear to be more segregated, Suzuki et al. (p. 1927) find that IRAK-4, a dominant protein kinase already known to be involved in signaling innate immune responses from Toll-like receptors, also supports signaling from the T cell receptor. Thus, mice lacking the IRAK-4 gene showed diminished acquired T cell immunity to viral infection.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)