COVER In this issue, Science begins its "Pathways of Discovery" feature--a yearlong series of monthly essays examining the complex routes by which science and scientists uncover knowledge about the world. In the cover image by artist Michael Gibbs, human figures traverse a mysterious and seemingly endless landscape of winding, intersecting, and splitting pathways. They have covered much territory, but their present positions suggest little about the ultimate lengths and destinations of their journeys. See page 253

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