COVER Four representations looking into the active site cleft of the large ribosomal subunit of Haloarcula. Synthesis of peptide bonds is catalyzed by ribosomal RNA in the active site, which contains the aminoacyl ends of the transfer RNAs (in contrasting colors). Clockwise from upper left: RNA (orange and white) and protein (blue), RNA domains coded by color, conserved proteins (yellow), and universally conserved RNA structure (blue). See page 920. [Images: P. Nissen et al.]

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