This Week in Science

Editor summaries of this week's papers.
Science 20 August 2004: 1073.
|Full Text »

Editorial:
Academic Health I

Donald Kennedy
Science 20 August 2004: 1077.
Summary »|   PDF »|  

Editors' Choice

Highlights of the recent literature.
Science 20 August 2004: 1079.
|Full Text »

NetWatch

Best of the Web in science.
Science 20 August 2004: 1085.
|Full Text »

 New Products

Science 20 August 2004: 1169.
PDF »|  

News of the Week

HUMAN SUBJECTS RESEARCH:
Pediatric Study of ADHD Drug Draws High-Level Public Review

Jennifer Couzin
Science 20 August 2004: 1088-1089.
Summary »|   Full Text »|   PDF »|  

BIOSAFETY:
Citizens Sue to Block Montana Biodefense Lab

Jocelyn Kaiser
Science 20 August 2004: 1088.
Summary »|   Full Text »|   PDF »|  

RESEARCH POLICY:
Economist to Guide $22 Billion E.U. Science Programs

Gretchen Vogel
Science 20 August 2004: 1089.
Summary »|   Full Text »|   PDF »|  

ECOLOGY:
Reproductive Failure Threatens Bird Colonies on North Sea Coast

Fiona Proffitt
Science 20 August 2004: 1090.
Summary »|   Full Text »|   PDF »|  

CONFLICTS OF INTEREST:
Report Suggests NIH Weigh Consulting Ban

Jocelyn Kaiser
Science 20 August 2004: 1090.
Summary »|   Full Text »|   PDF »|  

MEXICO:
Government Uses Carrot, Stick to Retain Graduate Students

Yudhijit Bhattacharjee
Science 20 August 2004: 1091.
Summary »|   Full Text »|   PDF »|  

AIDS RESEARCH:
Cambodian Leader Throws Novel Prevention Trial Into Limbo

Jon Cohen
Science 20 August 2004: 1092.
Summary »|   Full Text »|   PDF »|  

ORGANIC CHEMISTRY:
Druglike Molecules Mimic Gene Switches

Robert F. Service
Science 20 August 2004: 1092.
Summary »|   Full Text »|   PDF »|  

COGNITION:
Life Without Numbers in the Amazon

Constance Holden
Science 20 August 2004: 1093.
Summary »|   Full Text »|   PDF »|  

ScienceScope

Science 20 August 2004: 1091.
|Full Text »

Random Samples

Science 20 August 2004: 1102.
|Full Text »

News Focus

CLIMATOLOGY:
Stormy Forecast for Climate Science

Andrew Lawler
Science 20 August 2004: 1094-1097.
Summary »|   Full Text »|   PDF »|  

CLIMATOLOGY:
Stitching Together a Global System of Systems

Andrew Lawler
Science 20 August 2004: 1096.
Summary »|   Full Text »|   PDF »|  

OCEANOGRAPHY:
New Dead Zone Off Oregon Coast Hints at Sea Change in Currents

Robert F. Service
Science 20 August 2004: 1099.
Summary »|   Full Text »|   PDF »|  

ECOLOGICAL SOCIETY OF AMERICA MEETING:
Bees From the Rainforest Add Up to a $62,000 Coffee Buzz

Jay Withgott
Science 20 August 2004: 1100.
Summary »|   Full Text »|   PDF »|  

ECOLOGICAL SOCIETY OF AMERICA MEETING:
Are Invasive Species Born Bad?

Jay Withgott
Science 20 August 2004: 1100-1101.
Summary »|   Full Text »|   PDF »|  

ECOLOGICAL SOCIETY OF AMERICA MEETING:
Fighting Sudden Oak Death With Fire?

Jay Withgott
Science 20 August 2004: 1101.
Summary »|   Full Text »|   PDF »|  

Letters

This Week's Letters

Science 20 August 2004: 1104.
Summary »|   PDF »|  

 Another Group at High Risk for HIV

Edward H. Allison and Janet A. Seeley
Science 20 August 2004: 1104.
Full Text »|   PDF »|  

 Taxonomists and Conservation

James T. Martin;, Quentin D. Wheeler, Peter H. Raven, and Edward O. Wilson
Science 20 August 2004: 1104-1105.
Full Text »|   PDF »|  

 Taxonomists and the CBD

R. Geeta, Andre Levy, J. Matt Hoch, Melissa Mark;, Quentin D. Wheeler, Peter H. Raven, and Edward O. Wilson
Science 20 August 2004: 1105-1106.
Full Text »|   PDF »|  

 Taxonomy: Exploring the Impediment

Christopher H. C. Lyal and Anna L. Weitzman
Science 20 August 2004: 1106.
Full Text »|   PDF »|  

 Museum Collections and Taxonomy

Douglas Causey, Daniel H. Janzen, A. Townsend Peterson, David Vieglais, Leonard Krishtalka, James H. Beach, and Edward O. Wiley
Science 20 August 2004: 1106-1107.
Full Text »|   PDF »|  

 Taxonomy and Natural History

Allen M. Young
Science 20 August 2004: 1107.
Full Text »|   PDF »|  

 CORRECTIONS AND CLARIFICATIONS

Science 20 August 2004: 1107.
Full Text »|  

Books et al.

CHEMISTRY:
Molecular Topographies

David C. Clary
Science 20 August 2004: 1108-1109.
Summary »|   Full Text »|   PDF »|  

MUSEUMS:
Nota Bene: Education Can Be Fun

Orla Smith
Science 20 August 2004: 1108-1109.
Summary »|   Full Text »|   PDF »|  

 Books Received

Science 20 August 2004: 1108.

Policy Forum

INTELLECTUAL PROPERTY:
Commons-Based Strategies and the Problems of Patents

Yochai Benkler
Science 20 August 2004: 1110-1111.
Summary »|   Full Text »|   PDF »|  

Perspectives

PHYSIOLOGY:
Enhanced: Lactic Acid--The Latest Performance-Enhancing Drug

David Allen and Håkan Westerblad
Science 20 August 2004: 1112-1113.
Summary »|   Full Text »|   PDF »|  

IMMUNOLOGY:
UNGstoppable Switching

Shyam Unniraman, Sebastian D. Fugmann, and David G. Schatz
Science 20 August 2004: 1113-1114.
Summary »|   Full Text »|   PDF »|  

PHYSICS:
Arrival of the Fermion Superfluid

Tin-Lun Ho
Science 20 August 2004: 1114-1115.
Summary »|   Full Text »|   PDF »|  

PALEOBIOLOGY:
Decoding the Ediacaran Enigma

Martin Brasier and Jonathan Antcliffe
Science 20 August 2004: 1115-1117.
Summary »|   Full Text »|   PDF »|  

CHEMISTRY:
Zinc-Zinc Bonds: A New Frontier

Gerard Parkin
Science 20 August 2004: 1117-1118.
Summary »|   Full Text »|   PDF »|  

MOLECULAR BIOLOGY:
RETROSPECTIVE: Francis Crick (1916-2004)

Leslie E. Orgel
Science 20 August 2004: 1118.
Summary »|   Full Text »|   PDF »|  

Review

Intramembrane Proteolysis: Theme and Variations

Michael S. Wolfe and Raphael Kopan
Science 20 August 2004: 1119-1123.
Abstract »|   Full Text »|   PDF »|  

Brevia

Intercontinental Spread of Pyrimethamine-Resistant Malaria

Cally Roper, Richard Pearce, Shalini Nair, Brian Sharp, François Nosten, and Tim Anderson
Science 20 August 2004: 1124.
Malaria parasites resistant to the most cost-effective treatment have migrated from Southeast Asia to Africa, where drug resistance is now spreading. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Observation of a One-Dimensional Tonks-Girardeau Gas

Toshiya Kinoshita, Trevor Wenger, and David S. Weiss
Science 20 August 2004: 1125-1128.
Published online 29 July 2004 [DOI: 10.1126/science.1100700] (in Science Express Reports)
Varying the interaction strength between bosons confined in one dimension can make them behave like fermions, confirming theory. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Observation of the Pairing Gap in a Strongly Interacting Fermi Gas

C. Chin, M. Bartenstein, A. Altmeyer, S. Riedl, S. Jochim, J. Hecker Denschlag, and R. Grimm
Science 20 August 2004: 1128-1130.
Published online 22 July 2004 [DOI: 10.1126/science.1100818] (in Science Express Reports)
Lithium atoms composing a cold Fermi gas become a superfluid as the interactions between paired atoms increase, producing a characteristic energy gap consistent with theory. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Pairing Gap and In-Gap Excitations in Trapped Fermionic Superfluids

J. Kinnunen, M. Rodríguez, and P. Törmä
Science 20 August 2004: 1131-1133.
Published online 22 July 2004 [DOI: 10.1126/science.1100782] (in Science Express Reports)
Lithium atoms composing a cold Fermi gas become a superfluid as the interactions between paired atoms increase, producing a characteristic energy gap consistent with theory. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Sudden Onset of Pitting Corrosion on Stainless Steel as a Critical Phenomenon

C. Punckt, M. Bölscher, H. H. Rotermund, A. S. Mikhailov, L. Organ, N. Budiansky, J. R. Scully, and J. L. Hudson
Science 20 August 2004: 1133-1136.
Direct observation shows that corrosion in steel can propagate suddenly and rapidly when small pits induce local chemical changes that catalyze further pitting. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Decamethyldizincocene, a Stable Compound of Zn(I) with a Zn-Zn Bond

Irene Resa, Ernesto Carmona, Enrique Gutierrez-Puebla, and Angeles Monge
Science 20 August 2004: 1136-1138.
A linear organometallic compound in which zinc is forced into an unusual +1 oxidation state has been synthesized. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Regions of Strong Coupling Between Soil Moisture and Precipitation

Randal D. Koster, Paul A. Dirmeyer, Zhichang Guo, Gordon Bonan, Edmond Chan, Peter Cox, C. T. Gordon, Shinjiro Kanae, Eva Kowalczyk, David Lawrence, Ping Liu, Cheng-Hsuan Lu, Sergey Malyshev, Bryant McAvaney, Ken Mitchell, David Mocko, Taikan Oki, Keith Oleson, Andrew Pitman, Y. C. Sud, Christopher M. Taylor, Diana Verseghy, Ratko Vasic, Yongkang Xue, and Tomohito Yamada
Science 20 August 2004: 1138-1140.
An ensemble of 12 climate models shows that precipitation is most influenced by soil moisture in the Great Plains, Sahel, and India, allowing for better weather prediction. Abstract »|   Full Text »|   PDF »|  

Modular Construction of Early Ediacaran Complex Life Forms

Guy M. Narbonne
Science 20 August 2004: 1141-1144.
Published online 15 July 2004 [DOI: 10.1126/science.1099727] (in Science Express Reports)
Latest Precambrian marine animals from Newfoundland, preserved in three dimensions, consist of frondlets that organize into larger fronds arranged on an organic skeleton. Abstract »|   Full Text »|   PDF »|  

Intracellular Acidosis Enhances the Excitability of Working Muscle

Thomas H. Pedersen, Ole B. Nielsen, Graham D. Lamb, and D. George Stephenson
Science 20 August 2004: 1144-1147.
Contrary to conventional wisdom, accumulation of lactic acid in muscle does not contribute to muscle fatigue but instead helps to maintain muscle function. Abstract »|   Full Text »|   PDF »|  

Local Nanomechanical Motion of the Cell Wall of Saccharomyces cerevisiae

Andrew E. Pelling, Sadaf Sehati, Edith B. Gralla, Joan S. Valentine, and James K. Gimzewski
Science 20 August 2004: 1147-1150.
The cell wall of the budding yeast exhibits nanoscale mechanical oscillations that may be caused by the concerted action of molecular motors. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Requirement of Rac1 and Rac2 Expression by Mature Dendritic Cells for T Cell Priming

Federica Benvenuti, Stephanie Hugues, Marita Walmsley, Sandra Ruf, Luc Fetler, Michel Popoff, Victor L. J. Tybulewicz, and Sebastian Amigorena
Science 20 August 2004: 1150-1153.
Immune cells that encounter foreign microbes first configure their cytoskeleton to facilitate presentation of antigen and, later, to form contacts with naïve T cells during activation. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin Remodeling

Michele A. West, Robert P. A. Wallin, Stephen P. Matthews, Henrik G. Svensson, Rossana Zaru, Hans-Gustaf Ljunggren, Alan R. Prescott, and Colin Watts
Science 20 August 2004: 1153-1157.
Immune cells that encounter foreign microbes first configure their cytoskeleton to facilitate presentation of antigen and, later, to form contacts with naïve T cells during activation. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression

Aleksandar Rajkovic, Stephanie A. Pangas, Daniel Ballow, Nobuhiro Suzumori, and Martin M. Matzuk
Science 20 August 2004: 1157-1159.
A specialized transcription factor found only in female germ cells orchestrates the development of the ovarian follicles after birth. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch

Nasim A. Begum, Kazuo Kinoshita, Naoki Kakazu, Masamichi Muramatsu, Hitoshi Nagaoka, Reiko Shinkura, Detlev Biniszkiewicz, Laurie A. Boyer, Rudolf Jaenisch, and Tasuku Honjo
Science 20 August 2004: 1160-1163.
Generation of genetic immune diversity requires the enzyme activation–induced cytidine deaminase but, contrary to some reports, not for the DNA cleavage step. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways

Raffaella Sordella, Daphne W. Bell, Daniel A. Haber, and Jeffrey Settleman
Science 20 August 2004: 1163-1167.
Published online 29 July 2004 [DOI: 10.1126/science.1101637] (in Science Express Reports)
Lung cancers that respond to the new drug gefitinib have an unusual ability to resist cell death signals. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Technical Comments

 Comment on "Network Motifs: Simple Building Blocks of Complex Networks" and "Superfamilies of Evolved and Designed Networks"

Yael Artzy-Randrup, Sarel J. Fleishman, Nir Ben-Tal, and Lewi Stone
Science 20 August 2004: 1107.
Full Text »|   PDF »|  

 Response to Comment on "Network Motifs: Simple Building Blocks of Complex Networks" and "Superfamilies of Evolved and Designed Networks"

Ron Milo, Shalev Itzkovitz, Nadav Kashtan, Reuven Levitt, and Uri Alon
Science 20 August 2004: 1107.
Full Text »|   PDF »|