The Gut: Inner Tube of Life

The Gut: Inside Out

Stephen Simpson, Caroline Ash, Elizabeth Pennisi, and John Travis
Science 25 March 2005: 1895.
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Foldout: The Inner Tube of Life

Science 25 March 2005: 1914.
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News

The Dynamic Gut

Elizabeth Pennisi
Science 25 March 2005: 1896-1899.
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What's Eating You?

Elizabeth Pennisi
Science 25 March 2005: 1897.
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A Mouthful of Microbes

Elizabeth Pennisi
Science 25 March 2005: 1899-1901.
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Viewpoint

No Organ Left Behind: Tales of Gut Development and Evolution

Didier Y. R. Stainier
Science 25 March 2005: 1902-1904.
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Reviews

Self-Renewal and Cancer of the Gut: Two Sides of a Coin

Freddy Radtke and Hans Clevers
Science 25 March 2005: 1904-1909.
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The Gut and Energy Balance: Visceral Allies in the Obesity Wars

Michael K. Badman and Jeffrey S. Flier
Science 25 March 2005: 1909-1914.
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Host-Bacterial Mutualism in the Human Intestine

Fredrik Bäckhed, Ruth E. Ley, Justin L. Sonnenburg, Daniel A. Peterson, and Jeffrey I. Gordon
Science 25 March 2005: 1915-1920.
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Immunity, Inflammation, and Allergy in the Gut

Thomas T. MacDonald and Giovanni Monteleone
Science 25 March 2005: 1920-1925.
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This Week in Science

Editor summaries of this week's papers.
Science 25 March 2005: 1835.
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Editorial:
Cancers of the Gut and Western Ills

Ian T. Johnson
Science 25 March 2005: 1839.
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Editors' Choice

Highlights of the recent literature.
Science 25 March 2005: 1841.
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NetWatch

Best of the Web in science.
Science 25 March 2005: 1847.
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 AAAS News & Notes

Science 25 March 2005: 1893.

 New Products

Science 25 March 2005: 1979.
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News of the Week

PALEOANTHROPOLOGY:
Discoverers Charge Damage to 'Hobbit' Specimens

Elizabeth Culotta
Science 25 March 2005: 1848.
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ETHICS:
Doctors Pay a High Price for Priority

Martin Enserink
Science 25 March 2005: 1848-1849.
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CAREER TRANSITIONS:
Panel Throws Lifeline to Bio Postdocs

Yudhijit Bhattacharjee
Science 25 March 2005: 1849.
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SCIENTIFIC MISCONDUCT:
Researcher Faces Prison for Fraud in NIH Grant Applications and Papers

Eli Kintisch
Science 25 March 2005: 1851.
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GENETICS:
Talking About a Revolution: Hidden RNA May Fix Mutant Genes

Elizabeth Pennisi
Science 25 March 2005: 1852-1853.
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PALEONTOLOGY:
Tyrannosaurus rex Soft Tissue Raises Tantalizing Prospects

Erik Stokstad
Science 25 March 2005: 1852.
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ASTRONOMY:
Alien Planets Glimmer in the Heat

Robert Irion
Science 25 March 2005: 1853.
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PALEOCLIMATE:
Ocean Flow Amplified, Not Triggered, Climate Change

Richard A. Kerr
Science 25 March 2005: 1854.
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PROTEOMICS:
Protein Chips Map Yeast Kinase Network

Robert F. Service
Science 25 March 2005: 1854-1855.
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MAGNETIC IMAGING:
Atom-Based Detector Puts New Twist on Nuclear Magnetic Resonance

Adrian Cho
Science 25 March 2005: 1855.
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ECOLOGY:
Savannah River Lab Faces Budget Ax

Eli Kintisch
Science 25 March 2005: 1857.
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PROPOSITION 71:
Proposed Legislation Threatens to Slow California Stem Cell Rush

Jon Cohen
Science 25 March 2005: 1857.
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ScienceScope

Science 25 March 2005: 1851.
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Random Samples

Science 25 March 2005: 1867.
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News Focus

EPIDEMIOLOGY:
Mounting Evidence Indicts Fine-Particle Pollution

Jocelyn Kaiser
Science 25 March 2005: 1858-1861.
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EPIDEMIOLOGY:
How Dirty Air Hurts the Heart

Jocelyn Kaiser
Science 25 March 2005: 1858-1859.
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EPIDEMIOLOGY:
Regulations Spark Technology Competition

Marie Granmar
Science 25 March 2005: 1860.
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U.S. EDUCATION RESEARCH:
Can Randomized Trials Answer the Question of What Works?

Yudhijit Bhattacharjee
Science 25 March 2005: 1861-1863.
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ASTRONOMY:
American Astronomers Lobby for the Next Big Thing

Robert Irion
Science 25 March 2005: 1864.
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INFECTIOUS DISEASES:
True Numbers Remain Elusive in Bird Flu Outbreak

Martin Enserink and Dennis Normile
Science 25 March 2005: 1865.
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Letters

This Week's Letters

Science 25 March 2005: 1873.
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 Abuse of Prisoners at Abu Ghraib

David Colquhoun;, Raj Persaud;, Vladimir J. Konecni;, David C. Musch;, Susan T. Fiske, Lasana T. Harris, and Amy J. C. Cuddy
Science 25 March 2005: 1873-1875.
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 Reinventing the Wheel in Ecology Research?

R. Warren Flint, Richard D. Kalke;, David Raffaelli, Bradley J. Cardinale, Amy L. Downing, Katharina A. M. Engelhardt, Jennifer L. Ruesink, Martin Solan, and Diane S. Srivastava
Science 25 March 2005: 1875-1876.
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 A Central Repository for Published Plasmids

Melina Fan, Judy Tsai, Benjie Chen, Kenneth Fan, and Joshua LaBaer
Science 25 March 2005: 1877.
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 CORRECTIONS AND CLARIFICATIONS

Science 25 March 2005: 1877.
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Books et al.

PALEONTOLOGY:
Ready for Their Close-Up

Hans Sues
Science 25 March 2005: 1878-1879.
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ECOLOGY:
Place Matters

Sahotra Sarkar
Science 25 March 2005: 1879.
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 Books Received

Science 25 March 2005: 1879.

Policy Forum

ETHICS:
Ethics: A Weapon to Counter Bioterrorism

Margaret A. Somerville and Ronald M. Atlas
Science 25 March 2005: 1881-1882.
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Perspectives

PHYSICS:
Bose-Einstein Condensates Interfere and Survive

Juha Javanainen
Science 25 March 2005: 1883-1885.
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CELL BIOLOGY:
Whither Model Organism Research?

Stanley Fields and Mark Johnston
Science 25 March 2005: 1885-1886.
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MOLECULAR BIOLOGY:
Signal Processing in Single Cells

Farren J. Isaacs, William J. Blake, and James J. Collins
Science 25 March 2005: 1886-1888.
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ATMOSPHERIC SCIENCE:
Enhanced: Something in the Air

Daniel M. Murphy
Science 25 March 2005: 1888-1890.
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EVOLUTION:
The Synthesis and Evolution of a Supermodel

Greg Gibson
Science 25 March 2005: 1890-1891.
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Brevia

Underwater Bipedal Locomotion by Octopuses in Disguise

Christine L. Huffard, Farnis Boneka, and Robert J. Full
Science 25 March 2005: 1927.
The absence of an internal skeleton does not prevent the octopus from walking on two of its arms. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Articles

Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles

Pamela F. Colosimo, Kim E. Hosemann, Sarita Balabhadra, Guadalupe Villarreal, Jr., Mark Dickson, Jane Grimwood, Jeremy Schmutz, Richard M. Myers, Dolph Schluter, and David M. Kingsley
Science 25 March 2005: 1928-1933.
Ancient armored, marine stickleback fish gave rise to numerous modern, freshwater species that lost their armor by repeated selection of a single cryptic allele. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Temporal Relationships of Carbon Cycling and Ocean Circulation at Glacial Boundaries

Alexander M. Piotrowski, Steven L. Goldstein, Sidney R. Hemming, and Richard G. Fairbanks
Science 25 March 2005: 1933-1938.
Changes in Earth's climate preceded changes in ocean circulation during the last glaciation and deglaciation. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

A New Population of Very High Energy Gamma-Ray Sources in the Milky Way

F. Aharonian, A. G. Akhperjanian, K.-M. Aye, A. R. Bazer-Bachi, M. Beilicke, W. Benbow, D. Berge, P. Berghaus, K. Bernlöhr, C. Boisson, O. Bolz, C. Borgmeier, I. Braun, F. Breitling, A. M. Brown, J. Bussons Gordo, P. M. Chadwick, L.-M. Chounet, R. Cornils, L. Costamante, B. Degrange, A. Djannati-Ataï, L. O'C. Drury, G. Dubus, T. Ergin, P. Espigat, F. Feinstein, P. Fleury, G. Fontaine, S. Funk, Y. A. Gallant, B. Giebels, S. Gillessen, P. Goret, C. Hadjichristidis, M. Hauser, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, W. Hofmann, M. Holleran, D. Horns, O. C. de Jager, I. Jung, B. Khélifi, Nu. Komin, A. Konopelko, I. J. Latham, R. Le Gallou, A. Lemière, M. Lemoine, N. Leroy, T. Lohse, A. Marcowith, C. Masterson, T. J. L. McComb, M. de Naurois, S. J. Nolan, A. Noutsos, K. J. Orford, J. L. Osborne, M. Ouchrif, M. Panter, G. Pelletier, S. Pita, G. Pühlhofer, M. Punch, B. C. Raubenheimer, M. Raue, J. Raux, S. M. Rayner, I. Redondo, A. Reimer, O. Reimer, J. Ripken, L. Rob, L. Rolland, G. Rowell, V. Sahakian, L. Saugé, S. Schlenker, R. Schlickeiser, C. Schuster, U. Schwanke, M. Siewert, H. Sol, R. Steenkamp, C. Stegmann, J.-P. Tavernet, R. Terrier, C. G. Théoret, M. Tluczykont, D. J. van der Walt, G. Vasileiadis, C. Venter, P. Vincent, B. Visser, H. J. Völk, and S. J. Wagner
Science 25 March 2005: 1938-1942.
A survey of the inner part of our Galaxy, the Milky Way, reveals eight enigmatic sources of high-energy gamma rays that may contribute to cosmic ray bombardment of Earth. Abstract »|   Full Text »|   PDF »|  

Chemical Detection with a Single-Walled Carbon Nanotube Capacitor

E. S. Snow, F. K. Perkins, E. J. Houser, S. C. Badescu, and T. L. Reinecke
Science 25 March 2005: 1942-1945.
The capacitance of carbon nanotube electrodes coated with particular chemicals changes rapidly in the presence of a certain vapor species, providing a highly specific and sensitive sensor. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Light Scattering to Determine the Relative Phase of Two Bose-Einstein Condensates

M. Saba, T. A. Pasquini, C. Sanner, Y. Shin, W. Ketterle, and D. E. Pritchard
Science 25 March 2005: 1945-1948.
Some of the atoms in two spatially separate Bose-Einstein condensates can be made to constructively interfere constructively with one another, producing an atom interferometer. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Cool La Niña During the Warmth of the Pliocene?

R. E. M. Rickaby and P. Halloran
Science 25 March 2005: 1948-1952.
Warm ocean temperatures in the Pacific about 5 million years ago possibly favored upwelling of cool waters in the eastern Pacific resembling a La Niña–like climate. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Soft-Tissue Vessels and Cellular Preservation in Tyrannosaurus rex

Mary H. Schweitzer, Jennifer L. Wittmeyer, John R. Horner, and Jan K. Toporski
Science 25 March 2005: 1952-1955.
Elastic soft tissues, intact blood vessels, and cells are well preserved inside the femur of a 70-million-year-old Tyrannosaurus rex. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont

Justin L. Sonnenburg, Jian Xu, Douglas D. Leip, Chien-Huan Chen, Benjamin P. Westover, Jeremy Weatherford, Jeremy D. Buhler, and Jeffrey I. Gordon
Science 25 March 2005: 1955-1959.
A microbe that resides in the gut helps mammals by feeding on otherwise indigestible plant polysaccharides and can survive on host polysaccharides when necessary. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Introduced Predators Transform Subarctic Islands from Grassland to Tundra

D. A. Croll, J. L. Maron, J. A. Estes, E. M. Danner, and G. V. Byrd
Science 25 March 2005: 1959-1961.
Introduced foxes in some Aleutian Islands preyed on native seabirds, reducing the amount of guano fertilizing the land and causing shrubs to replace grasslands. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Gene Regulation at the Single-Cell Level

Nitzan Rosenfeld, Jonathan W. Young, Uri Alon, Peter S. Swain, and Michael B. Elowitz
Science 25 March 2005: 1962-1965.
Gene expression varies with the concentration of the transcriptional activator in a relation that helps model cellular regulation. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Noise Propagation in Gene Networks

Juan M. Pedraza and Alexander van Oudenaarden
Science 25 March 2005: 1965-1969.
The accuracy of gene expression can be predicted from the contributions of random errors elsewhere in the cellular genetic network. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

RNA-Dependent Cysteine Biosynthesis in Archaea

Anselm Sauerwald, Wenhong Zhu, Tiffany A. Major, Hervé Roy, Sotiria Palioura, Dieter Jahn, William B. Whitman, John R. Yates, 3rd, Michael Ibba, and Dieter Söll
Science 25 March 2005: 1969-1972.
Showing how cysteine may have been added to the genetic code, an archaea uses the amino acid cysteine for protein synthesis by loading another amino acid on tRNA, then converting it to cysteine. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Structural Insights into the Activity of Enhancer-Binding Proteins

Mathieu Rappas, Jorg Schumacher, Fabienne Beuron, Hajime Niwa, Patricia Bordes, Sivaramesh Wigneshweraraj, Catherine A. Keetch, Carol V. Robinson, Martin Buck, and Xiaodong Zhang
Science 25 March 2005: 1972-1975.
The hydrolysis of ATP accompanying activator binding to the transcription initiation complex provides the energy to change the DNA structure and start transcription. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis in Mice

Takashi Sakatani, Atsushi Kaneda, Christine A. Iacobuzio-Donahue, Mark G. Carter, Sten de Boom Witzel, Hideyuki Okano, Minoru S. H. Ko, Rolf Ohlsson, Dan L. Longo, and Andrew P. Feinberg
Science 25 March 2005: 1976-1978.
Published online 24 February 2005 [DOI: 10.1126/science.1108080] (in Science Express Reports)
Demethylation of certain genes results in more colorectal tumors in mice, probably because the loss of imprinting of these genes delays maturation of intestinal tissue. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|